Abstract:
Objective To inv estigate the effect of Sband high power microwave(HPM)radiation on structure and amino acids transmitters of cerebral cor tex in rats.
Methods Rats were ex posed to Sband HPMwhich average power densities were respectively 2~90 mW/cm2.HEstaining, Toluidine blue staining and electr on telescope were used to study the change of the str ucture of cortex, and high performance liquid chro matogr aphy(HPLC)was used to study the changes of 4 amino acids(glutaminic acid, aspar ag ic acid, GABAand glycine)of cortex in 6 h and 1 d afterex posure to 10 and 50 mW/cm2 HPM.
Results Pycnosis and deep staining of neurons, deposits of synapse vesicles and bluring of synapses, fusion and dissociatio of myelin sheaths which were exposed to 10, 50 and 90 mW/cm2 HPMwere obser ved.The contents of the above four amino acids elevated more mar kedly on 6 h than those of controls, but on 1 d only the elev ation of GABAand glycine aft erexposure to 10 and 50 mW/cm2 HPM was observed.
Conclusion Sband HPMradiation can induce the injure of Nissel body, synapse and my elin sheath of neuron, and the disorder of amino acids in cerebral cortex.
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