羊脾多肽对小鼠免疫功能的影响

Experimental study on imune function of spleen polypeptides

摘要:
目的探讨羊脾多肽对小鼠免疫功能的影响.
方法分别以1, 3, 5g/(kg·d)羊脾多肽给小鼠连续灌胃30d后, 检测各项免疫指标.
结果羊脾多肽能使小鼠脾、胸腺增重, 明显刺激小鼠的脾淋巴细胞增值, 促进小鼠迟发型变态反应作用, 提高小鼠抗体生成细胞数, 提高小鼠的血清溶血素水平, 但促进小鼠单核-巨噬细胞碳廓清作用不明显, 增强小鼠的单核-腹腔巨噬细胞吞噬能力, 有效提高小鼠自然杀伤细胞活性.
结论羊脾多肽具有明显增强免疫力作用.

Abstract:
Objective To study the effect of sheep spleen polypeptides on immune function.
Methods Sheep spleen function was consecutively orally given to mice withe the doses of 1, 3, 5 g/(kg·d)for 30 days and then immune indexes were determined.
Results Sheep spleen polypeptides could significantly stimulate multiplication and transformation of mice's spleen lymphocytes; increased markedly the weight of spleen and the theymus; promoted delayed hypersensitivity; increased the quantity of antibody2producing cells; increased the level of serum hemolysin; promoted the expurgation effect and the phagocytic function of monocyte/macrophage and increased the activity of natural killer.
Conclusion Sheep spleen polypeptides can markedly increase immune function in mice.