J江某段有机污染物对大鼠肝肾毒性作用

李鹏; 崔志鸿; 刘胜学; 曹佳

doi:10.11847/zgggws2006-22-04-16

J江某段有机污染物对大鼠肝肾毒性作用

Effect of organic pollutants from J river on hepatic and renal toxicity of rats

摘要

摘要:
目的探讨J江某段有机污染物对大鼠的肝肾毒性。
方法固相萃取法提取江水中有机物, 分别以相当于源水4, 24, 144 L/(kg·bw)的剂量给予大鼠亚急性(14 d)灌胃染毒, 观察肝、肾组织病理改变、肝肾功能相关血清生化指标及脂质过氧化水平。
结果在144 L/(kg·bw)剂量组, 染毒大鼠肝、肾组织可出现以空泡变性为特征的病理损伤; 谷草转氨酶(AST)、尿酸(UA)、甘油三酯(TG)水平与对照组间差异有统计学意义(P < 0.05);肝、肾组织中总超氧化物歧化酶(T-SOD)活力和丙二醛(MDA)含量显著升高。
结论在较高的实验剂量时, J江某段有机提取物具有一定的肝肾毒性, 脂质过氧化作用可能是其损伤肝肾机制之一。

Abstract:
Objective To investigate the hepatic and renal toxicity of organic pollutants from J River in rats.
Methods Organic extract was collected with method of solid phase extraction.At 4, 24, 144 L/(kg·bw)doses of pouring into stomach, patholo gical changes, hepatic and renal function and lipid perox idation were studied in subacute tox icity test(14 d).
Results In the 144 L/kg dose group, vacuolar degeneration was found both in liver and kidneys.Values of aspartate transaminase (AST), uric acid(UA)and trigly ceride(TG)in serum increased greatly.High levels of total superoxide dismutase(T-SOD)activ ity and malondialdehyde(MDA)were detected in the two or gans.
Conclusion In the higherex perimental dose, organic extract from J River has potential toxicity of the liver and kidney, and lipid peroxidation may be one of the mechanisms of the impairing.

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