高碘对仔鼠甲状腺功能影响及硒干预作用

郭怀兰; 徐健; 杨雪锋; 侯晓晖; 陈骁熠; 孙秀发

doi:10.11847/zgggws2006-22-08-24

高碘对仔鼠甲状腺功能影响及硒干预作用

Effect of excess iodine on function of thyroid in progeny of mice and intervention of selenium

摘要

摘要:
目的研究高碘摄入对小鼠仔代甲状腺的影响及硒的干预作用。
方法将60只Balb/c小鼠随机分为4组: 正常对照组、高碘组(Ⅰ 3 000μg/L)、单独补硒组(Se 200μg/L)、高碘(Ⅰ 3 000μg/L)+Se(200μg/L)组。各组分别饮用自来水、高碘水、加硒水和高碘加硒水, 饲以纯系鼠饲科。4个月后, 测尿碘, 雌雄交配。观察14 d龄仔鼠甲状腺病理变化, 测定14 d龄和28 d龄仔鼠血清促甲状腺激素(TSH)、总T₄(TT₄)、总T₃(TT₃)和rT3水平。
结果高碘组14d龄仔鼠出现弥漫胶质性甲状腺肿, 高碘补硒组甲状腺肿减轻; 14 d龄仔鼠高碘组因清TT₄水平显著低于对照组和高碘加硒组(P < 0.05), 而TT₃有降低的趋势, 高碘组TSH显著高于对照组和高碘加硒组(P < 0.05);28 d龄仔鼠血清TT₄和TT₃水平以及TSH水平组间差异无统计学意义。
结论高碘引起仔鼠甲状腺形态和功能异常改变, 补硒具有一定改善作用。

Abstract:
Objective To study the influence of excess iodine intake on function and morphology of thryoid in progeny of mice and intervention of selenium.
Methods 60 Balb/c mice were divided randomly into four groups: control group, excessiodine group(3 000μg/L Ⅰ), supplement selenium group(200μg/L Se)and excess iodine plus selenium(200 μg/L Se)group.The mice were given drinking water including some dosage of iodine or selenium.At the end of the fourth month, urinary iodine was determined and then the mice were mated.
Results On the postnatal day 14, the mice in excess iodine group showed coloid goiter, serum TT₄ level was lower significantly and serum TSH level was higher in excess iodine group than control group and excess iodine plus selenium.On postnatal day 28, no significance was found in serum TT₄, TT₃ and TSH level between four groups.
Conclusion excess iodine intake may damage the function and morphology of thy roid in progent of mice and selenium supplementation exerted favorable effects on it.

HTML全文

参考文献(5)

施引文献

资源附件(0)