Abstract: Objective To calculate the depression level in the parents with epileptic children,and to study the affecting factors of parental depression.Methods The subjects were 341 parents with 4~18 years old epileptic children.The question-naire of Hospital Anxiety and Depression(HAD)was used.Results 40.3 percent of the parents had different degree of depression,and mild depression was 25.5%,moderate depression is 10.3%,severe depr ession was 51.0%.Parental depression correlated significantly with the children's living place(city/county/village),seizure frequency,familial economic conditions and parental understanding level of the relevant knowledge of epilepsy.Conclusion The epileptic children's parental depression is severe.Strengthening the propaganda and knowledge education of epilepsy combined by controlling the children's seizure;parental depression can be alleviated.