Abstract: Objective To know the condition about KAP(knowledge,attitude and practice)of AIDS among junior high school students of Nanshan district in Shenzhen in order to provide reference for carrying outhealth education on AIDS prevention in school.Methods 3 528 students from 10 junior high schools of Nanshan district in Shenzhen were surveyed with questionnaire including demographical information,AIDS related knowledge,approaches of knowledge acquired and the need of health,AIDS related attitude and practice.Results The average rate of right answer about basic knowledge,spreading route,non-spreading route and prevention knowledge were 55.1%,77.1%,67.8% and 61.1%respectively.There were differences between sexes and among grades about some knowledge items;the scores of attitude related AIDS were high.Girl students and students of grade two were prone to show sympathetic and tolerant attitude towards AIDS patients or HIV-infected persons;the rate of some risk behaviors related AIDS such as smoking,drinking,falling in love in school and sex behavior were 9.6%,45.8%,17.5% and 1.1% respectively,which was different between sexes and among grades,the incidence rate was bigger in boy students than in girl students,and was bigger in higher grades than in lower grades.Conclusion There are differences between sexes and among grades on some knowledge,attitude and practice,different contents of health education.AIDS prevention should be carried out towards different students in schools.