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李明成, 张晓英, 郑华. 子宫颈糜烂与生殖道人乳头瘤病毒感染关系[J]. 中国公共卫生, 2007, 23(8): 951-952. DOI: 10.11847/zgggws2007-23-08-28
引用本文: 李明成, 张晓英, 郑华. 子宫颈糜烂与生殖道人乳头瘤病毒感染关系[J]. 中国公共卫生, 2007, 23(8): 951-952. DOI: 10.11847/zgggws2007-23-08-28
LI Ming-Cheng, ZHANG Xiao-ying, ZHENG Hua. Study on human papilloma virus infection association with cervical erosion among female congential tract[J]. Chinese Journal of Public Health, 2007, 23(8): 951-952. DOI: 10.11847/zgggws2007-23-08-28
Citation: LI Ming-Cheng, ZHANG Xiao-ying, ZHENG Hua. Study on human papilloma virus infection association with cervical erosion among female congential tract[J]. Chinese Journal of Public Health, 2007, 23(8): 951-952. DOI: 10.11847/zgggws2007-23-08-28

子宫颈糜烂与生殖道人乳头瘤病毒感染关系

Study on human papilloma virus infection association with cervical erosion among female congential tract

  • 摘要: 目的 探讨女性生殖道感染人乳头瘤病毒基因类型及与子宫颈糜烂关系,为宫颈癌防治提供依据.方法 收集454份子宫颈糜烂标本,分成尖锐湿疣(CA)组和非CA组,采用免疫组化法和PCR技术检测人乳头瘤病毒(HPV)基因类型.结果 免疫组化法检测宫颈糜烂感染HPV阳性率,CA组为67.8%,非CA组为47.7%.PCR检测宫颈糜烂Ⅰ°、Ⅱ°、Ⅲ°感染HPV阳性率,CA组Ⅰ°55.5%,Ⅱ°64.7%,Ⅲ°83.3%.非CA组Ⅰ°32.8%,Ⅱ°49.6%,Ⅲ°62.3%.HPV-DNA类型以6,11,16,18,58,45,33型为主.结论 本地区宫颈糜烂患者有较高的HPV感染率,并与糜烂程度呈正相关,监测和控制女性生殖道HPV感染对宫颈癌防治具有重要意义.

     

    Abstract: Objective To explore the genotype and distribution of humam papilloma viruses among cervical erosion patients,and to guide the preventing and treat ing cancer of uterine cervix.Methods T he cervical erosion specimens were collected and divided into two groups,the CA group and no-CA group.The immunohistochemistry assay and PCR technique were used to detect the genotypes of HPV-DNA.Results The 76 cases(67.8%)in CA g roup and the 163 cases(47.7%) in no-CA group were confirmed to be HPV-DNA positive.T he positive rates of HPV were Ⅰ° 55.5%,Ⅱ° 64.7% and Ⅲ° 83.3% in CA group;and Ⅰ° 32.8%,Ⅱ° 49.6% and Ⅲ° 62.3% in non-CA group among cervical erosion patients respectively.The genotype of HPV-DNA was 6,11,16,18,58,45 and 33.Conclusion T here is hig her incidence of HPV among cerv ical erosion pat ients in the region,and the incidence of HPV has a positive association ith the cervical erosion deg rees.It is of paramount importance to control HPV infection and treat cervical erosion effectively for preventing and treating cancer of uterine cervix.

     

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