Abstract: Objective To explore the relationship of insulin resistance with risk factors of cardiovascular disease and their clustering in Mongolian people.Methods 1 090 subjects were investigated for blood pressure,height,weight,waistline,hipcircum,and their blood specimens were collected for glucose,insulin and serum lipids analysis.The whole subjects were divided into 4 groups according to their insulin resistance index(IR)level,and compared differences in risk factors and the clustering of risk factors between groups.Results After being adjusted for age and gender,BMI,WHR,SBP,DBP,TG,FPG and prevalence of essential hypertension increased with the raise of IR,P<0.05.IR had correlations with WHR,SBP,and TG.The rates of clustering of cardiovascular diseases risk factors from the lowest to the highest quartile groups of IR level were 33.8%,44.5%,47.2%,66.5%,respectively(χ²=601 265 7,P<0.000 1).Conclusion Insulin resistance was correlated with several cardiovascular diseases risk factors and increased their level and clustering.