阿尔茨海默病患者血清抗氧化酶与维生素E

钞虹; 赵长峰; 张俊黎; 杨晓东; 王淑娥; 赵玉萍

doi:10.11847/zgggws2007-23-12-34

阿尔茨海默病患者血清抗氧化酶与维生素E

Serum antioxidase and vitamin E of patients with Alzheimer disease

摘要

摘要: 目的分析阿尔茨海默病患者与健康人血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、铜兰蛋白(CP)、过氧化氢酶(CAT)、丙二醛(MDA)、维生素E的含量及其意义。方法采用病例对照研究,以在山东省精神卫生中心临床检验确诊的64例阿尔茨海默病患者为病例组,以社区45名健康者为对照组,测定分析血清中抗氧化酶和维生素E的含量。结果阿尔茨海默病患者血清SOD活力(60.25±6.59)U/ml、GSH-PX活力(149.60±27.56)酶活力单位、CAT活力(1.64±0.80)U/ml、维生素E含量(5.74±1.27)μg/ml明显降低,而阿尔茨海默病患者血清CP活力(49.31±5.67)U/L、MDA含量(6.54±0.81)nmol/ml明显升高差异有统计学意义(P<0.01)。结论阿尔茨海默病患者血清中SOD、MDA、GSH-PX、CP、CAT、维生素E含量水平与健康人比较,差异有统计学意义,可以作为阿尔茨海默病预防控制的重要指标。

Abstract: Objective To compare the blood serum contents o f superox ide dismutase,glutathione perox idase,ceruloplasmin,catalase,malonaldehyde,vitamin E between Alzheimet disease patients and the well-beings,as well as its significance.Methods Using case-control research,to collect 64 definite Alzheimer disease patients from mental health center of ShanDong and 45 well-beings from community.To analyze the blood serum contents of ant ioxidase and vitamin E.Results The vigor of superox ide dismutase(60.25±6.59)U/ml,glutathione peroxidase(149.60±27.56)unit of enzyme activitv,catalase(1.64±0.80)U/ml and the content of vitamin E(5.74±1.27)Ug/ml were obviously low in Alzheimer disease patients; however,the vigor of ceruloplasmin(49.31±5.67)U/L and the content of malonaldehyde(6.54±0.81)nmol/ml were obviously high.There were statistical significance(P<0.01).Conclusion The results of SOD,GSH-PX,CP,CAT,MDA and vitamin E have statistical discrepancy by comparing Alzheimet disease patients and the well-beings,being momentous indexes of pr ecaution and control AD.

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