Abstract: Objective To observe prerention of taurine and vitamin C from RNA damage of cerebral neurons in mice exposed to arsenic.Methods Forty mice were divided into 4 groups,one control and one experimental group receiving As₂O₃,two antagonistic groups receiving taurine with As₂O₃ or vitamin C with As₂O₃,were administered for 60 days.Immunohisto-chemistry method was used to investigate 8-nitroguanine expression in cerebral neurons of mice.Results The pathological changes and stronger expression of 8-nitroguanine were observed in the brain cortex of mice exposed to arsenic.In the two antagonistic groups,the light pathological changes and exprexssion of 8-nitroguanine were shown in brain tissue of mice.Conclusion Taurine and vitamin C may have the preventive effect on RNA damage of cerebral neurons in mice exposed to arsenic.