Abstract: Objective To investigate the prevalence of hyperuricemia and its risk factors in the general adult population aged 35～64 years in Jinan.Methods To analyze data on 4 041 residents aged 35～64 years from the cross-sectional survey of Jinan.Physical examination was carried out and fasting blood was tested.Data were analyzed by multivariate Logistic regression models.Results 1 979 men and 2 062 women participanted in the study 16.4% of men and 2.1% of women had hyperuricemia,which was defined as serum uric acid≥417μmol/L in men and≥357μmol/L in women.Multivariate Logistic regression models found thathypertriglyceridemia(OR 6.155,95%CI 4.354～8.701),hypercholesteremia(OR 2.853,95%CI 1.796～4.531),male gender(OR 2.749,95%CI 1.781～4.245),hypertension(OR 1.884,95%CI 1.320～ 2.687),central obesity(OR 1.834,95%CI 1.209～2.781)were associated with increased risk of hyperuricemia,however,living in rural areas(OR 0.266,95%CI 0.177～0.398)and alcohol consumption(OR 0.807,95%CI 0.706～0.892)were associated with reduced risk of hyperuricemia.Conclusion Hypertriglyceridemia,hypercholesteremia,male gender,hypertension,central obesity are associated with increased risk of hyperuricemia.Alcohol consumption and living in rural areas are associated with reduced risk of hyperuricemia.