孕妇血清铁锌水平与镉毒效应关系

王海燕; 王克跃; 杨莉萍

doi:10.11847/zgggws2008-24-06-02

孕妇血清铁锌水平与镉毒效应关系

Correlation between status of ferrum, zinc and toxicity of cadmium in pregnant women

摘要

摘要: 目的探讨孕妇和非孕妇体内铁、锌状态与镉水平及其毒作用间的相关性。方法对98名孕妇和73名非孕妇分别测定血镉(BCd)、血清铁(SFe)、血清锌(SZn)、血红蛋白(Hb)、血清铁蛋白(SF)、尿镉(UCd)、尿金属硫蛋白(UMt)、尿β₂-微球蛋白(Uβ₂-MG)、N-乙酰-β-D-氨基葡萄糖苷酶(UNAG),并进行相关分析。结果孕妇组SZn、Hb、SF含量均明显低于非孕妇组,而UCd、BCd、UMt、Uβ₂-MG、UNAG、低SZn率、贫血率均高于非孕妇组;分血组BCd、UCd、UMt、Uβ₂-MG、UNAG均高于非贫血组;UNAG、Uβ₂-MG随血锌增加而降低;孕妇组镉毒效应随尿镉增高而升高;Hb与UCd、BCd、Uβ₂-MG和UMt呈负相关;SF与UCd呈负相关;SZn与UNAG、UMt、Uβ₂-MG呈负相关。结论缺铁能促进镉吸收,使镉进入体内的量增加;锌对镉引起的肾损伤有拮抗作用。

Abstract: Objective To investigate the correlation between ferrum and zinc status and toxic effects of cadmium in pregnant women.Methods BCd,SFe,SZn,Hb,SF,U Cd,UMt,Uβ₂-MG and UNAG in the blood,serum or urine were measured in 98 pregnant women and 73 non-pregnant women.Correlation analysis was carried out.Results The contents of SZn,Hb and SF were lower,but the contents of UCd,BCd,UMt,Uβ₂-MG,UNAG,percentage of anemia and low SZn in the pregnant women were higher than that in non-pregnant women.The contents of BCd,UCd,UMt,Uβ₂-MG and UNAG were higher in anemia group than that in non-anemia group.With the increase of SZn content,UNAG and Uβ₂-MG decreased and toxic effect of Cd increased with the increase of UCd content.Hb was negatively correlated with UCd,BCd,Uβ₂-MG and UMt.SF was negatively correlated with UCd.Meanwhile,SZn was negatively correlated with UNAG,UMt and Uβ₂-MG.Conclusion Ferrum deficiency can promote the absorption of cadmium,and zinc can antagonize the injury caused by cadmium in kidney.

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