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胡松林, 丁建祖, 曾肖芃, 严小岚, 楼涤, 沈丽英. 肺结核治疗后抗体持续时间动态分析[J]. 中国公共卫生, 2008, 24(6): 667-668. DOI: 10.11847/zgggws2008-24-06-18
引用本文: 胡松林, 丁建祖, 曾肖芃, 严小岚, 楼涤, 沈丽英. 肺结核治疗后抗体持续时间动态分析[J]. 中国公共卫生, 2008, 24(6): 667-668. DOI: 10.11847/zgggws2008-24-06-18
HU Song-lin, DING Jian-zu, ZENG Xiao-fan, . Dynamic observation on duration of TB-antibody positive in patients treated formally as pulmonary tuberculosis[J]. Chinese Journal of Public Health, 2008, 24(6): 667-668. DOI: 10.11847/zgggws2008-24-06-18
Citation: HU Song-lin, DING Jian-zu, ZENG Xiao-fan, . Dynamic observation on duration of TB-antibody positive in patients treated formally as pulmonary tuberculosis[J]. Chinese Journal of Public Health, 2008, 24(6): 667-668. DOI: 10.11847/zgggws2008-24-06-18

肺结核治疗后抗体持续时间动态分析

Dynamic observation on duration of TB-antibody positive in patients treated formally as pulmonary tuberculosis

  • 摘要: 目的 了解肺结核(pulmonary TB)治疗后病人血清抗结核抗体持续时间,为肺结核血清流行病学调查和结核病疫情分析提供科学依据。方法 采用Dyna-Gen公司生产的结明(MycoDot-TM)结核病快捷诊断试剂盒,对肺结核治疗后病人作每隔3个月血清抗结核抗体检测,连续观察15个月。另选择健康体检人群作对照比较。结果 205例治疗后病人完成全程观察190例,治疗后每3个月抗结核抗体的阳性人数逐渐下降,9个月时下降最明显,与健康对照比较差异无统计学意义(χ2=2.4391,P>0.05)。不同年龄、不同类型的肺结核病人血清抗结核抗体持续时间各有不同,经统计分析其意义也有所不同。结论 肺结核治疗后病人抗结核抗体的持续时间大约为9~12个月,病灶范围广及治疗后以增殖性病灶为主的患者抗结核抗体的持续时间较长;肺结核在治疗后短期内抗结核体抗阳性不能作为结核病活动的依据;若在治疗后9~12个月复查,抗结核抗体呈阳性反应,则警惕肺结核复发的可能。

     

    Abstract: Objective To investigate the duration of TB antibody positive in patients treated formally as pulmonary tuber culosis and provide evidence for seroepidemiological survey on pulmonary tuberculosis and epidemic situation of TB.Methods In 15 months,the TB antibody in patients treated as pulmonary tuber culosis were detected every 3 months using rapid test TB diagnostic kit(MyCoDot TM)produced by Dyna Gen corporation,and compared with normal health examination group.Results 190 cases were implemented whole range observation in 260 patients.Positive cases descended every 3 months,and the descent of ninth month was most obvious.There was no significant difference between the patients and the normal(χ2=2.4391,P>0.05).The duration of the TB antibody positive between different ages and types in pulmonary tuber culosis patients was distinct and the difference was significant.Conclusion The duration of the TB antibody positive in patients treated formally as pulmonary tuberculosis was about 9~12 months.The duration of the TB antibo dy positive in patients extensive focus prior treatment and proliferating focus post treatment was longer.The positive TB antibody short term after treated couldn't be considered as clinical evidence of active TB.If the TB antibody showed positive reaction 9~12 months after treatment,the possibility of relapse tuberculosis should be considered.

     

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