Abstract: Objective To learn and analyse spreading trend of HIV infectin in drug users and their characteristics of AIDS related behaviors in Liuzhou so as to provide basis for the government to draw up rules to prevent and control AIDS.Methods The data of behavioral and serological surveillance among drug users in 2003~2006 was analyzed.Results Heroin injection was the major drug used by the subjects.Most of the drug users were 20~39 years old,and the ratio of men to women is 4 to 1.48.7 percent of the drug users had experienced drug injection in 2003,and 24.3 percenthave experienced drug injection in 2006.300 cases of HIV infection were found,among them 236 cases shared needles with others.18.42 percent of subjects showed HIV antibody positive,which belong to medium spreading and the trend descended by the year.Of all the drug users 92.69 percent experienced drug injection,among them 30.20 percent shared needles with others.35.12 percent of drug users behaved badly and dang erously in selling and buying of drugs.8.1 percent of drug users never use condoms and 1.5 percent every time and 90.04 percent sometimes use condoms in sexual activity with high risk of HIV infection.Conclusion The investigation shows that there lies some potential factors for the drug users to speed up HIV infection in Liuzhou.Therefore health education must be streng thened and some useful measurements should be taken to intervene the drug using behaviors.