Abstract: Objective To investigate the protective effect of grape procyanidins(GPC)on oxidiation injury of people exposed to nuclear radiation.Methods Sixty people ex posed to nuclear radiation were divided into exper imental group and control group randomly.The exper imental group were orally given 100 mg GPC per day for 60 days.Blood was drawn at 1 st and 60th day of the experiment.Total antioxo dative capacity(T-AOC),malon-dialdehy de(MDA),glutathione peroxidast(GSH-Px),superoxide dismutase(SOD)and lymphocytes proliferation activity were determind.Results T-AOC,MDA and lymphocytes proliferation act ivity of the control group was 16.02±1.89 U/ml,4.40±0.35 nmol/ml and 0.82±0.07 at 60th day,respectively.Those of the exper imental group was 17.07±1.91 U/ml,4.12±0.37 nmol/ml and 0.87±0.09,respectively.All the differences between two groups were significant(P<01 05).Conclusion GPC can to some extent protect people exposed to nuclear radiation from oxidiation injury.