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付保荣, 曹向宇, 惠秀娟, 李法云, 谢明, 常浩. 杀菌剂粉唑醇遗传毒性试验研究[J]. 中国公共卫生, 2008, 24(9): 1140-1141. DOI: 10.11847/zgggws2008-24-09-61
引用本文: 付保荣, 曹向宇, 惠秀娟, 李法云, 谢明, 常浩. 杀菌剂粉唑醇遗传毒性试验研究[J]. 中国公共卫生, 2008, 24(9): 1140-1141. DOI: 10.11847/zgggws2008-24-09-61
FU Bao-rong, CAO Xiang-yu, HUI Xiu-juan, . Research on genotoxicity of bactericide flutriafol[J]. Chinese Journal of Public Health, 2008, 24(9): 1140-1141. DOI: 10.11847/zgggws2008-24-09-61
Citation: FU Bao-rong, CAO Xiang-yu, HUI Xiu-juan, . Research on genotoxicity of bactericide flutriafol[J]. Chinese Journal of Public Health, 2008, 24(9): 1140-1141. DOI: 10.11847/zgggws2008-24-09-61

杀菌剂粉唑醇遗传毒性试验研究

Research on genotoxicity of bactericide flutriafol

  • 摘要: 目的 探讨杀虫剂粉唑醇的遗传毒性。方法 应用Ames试验、小鼠骨髓嗜多染红细胞微核试验、慧星试验研究粉唑醇的遗传毒性。结果 Ames试验中,TA97、TA98、TA100和TA102 4个标准菌株无论代谢活化或非代谢活化,皆为阴性结果;小鼠骨髓嗜多染红细胞微核试验,与阴性对照组比较,差异无统计学意义;慧星试验中各评价指标与溶剂对照组比较差异无统计学意义。慧星试验剂量80 mg/(kg·bw)时,尾部DNA含量与溶剂对照组比较差异有统计学意义(P<0.05),而其他评价指标与溶剂对照组比较差异无统计学意义。Ames试验、小鼠骨髓嗜多染红细胞微核试验、慧星试验试验结果均为阴性。结论 在本次实验条件下,粉唑醇无遗传毒性。

     

    Abstract: Objective To study the genotoxicity of bactericide flutriafol.Methods The Ames test,micronucleus test and comet assay were used to detect the g enotoxicity of bactericide flutriafol.Results With and without S9 activation,there were negative results of the TA97,TA98,TA100 and TA102 str ains in A mes test.The micronucleus rates in all doses were not significantly different from that of the control group.For the tail DNA% of comet assay there was a significant difference between the negative control and the treated group(P>0.05)in dose of 80 mg/(kg·bw),while there was no significant difference between the negative control and the treated groups(P<0.05)in other dose.The results of genetic toxicity tests were all negative.Conclusion The bactericide flutriafol had no genetic toxicity in this test.

     

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