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刘欢, 黄国伟, 孙志华, 王永明, 任大林. 叶酸联合维生素B6/B12对脑缺血半暗带区影响[J]. 中国公共卫生, 2009, 25(1): 52-54. DOI: 10.11847/zgggws2009-25-01-24
引用本文: 刘欢, 黄国伟, 孙志华, 王永明, 任大林. 叶酸联合维生素B6/B12对脑缺血半暗带区影响[J]. 中国公共卫生, 2009, 25(1): 52-54. DOI: 10.11847/zgggws2009-25-01-24
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LIU Huan, HUANG Guo-wei, SUN Zhi-hua, . Effects of folic acid,vitamin B6 and vitamin B12 on ischemic penumbra in cerebral ischemia rats[J]. Chinese Journal of Public Health, 2009, 25(1): 52-54. DOI: 10.11847/zgggws2009-25-01-24
Citation: LIU Huan, HUANG Guo-wei, SUN Zhi-hua, . Effects of folic acid,vitamin B6 and vitamin B12 on ischemic penumbra in cerebral ischemia rats[J]. Chinese Journal of Public Health, 2009, 25(1): 52-54. DOI: 10.11847/zgggws2009-25-01-24
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叶酸联合维生素B6/B12对脑缺血半暗带区影响

Effects of folic acid,vitamin B6 and vitamin B12 on ischemic penumbra in cerebral ischemia rats

    摘要
  • 摘要: 目的 研究叶酸(FA)、维生素B6(VB6)和维生素B12(VB12)对局灶性脑缺血-中脑动脉闭塞(MCAO)大鼠缺血半暗带区(ischemic penumbra,IP)的影响。方法 将SD大鼠随机分为中脑动脉闭塞模型组(MCAO)、MCAO+叶酸组(MCAO+FA)和MCAO+复合维生素(叶酸+VB6+VB12)组(MCAO+CV);预防性给药28 d后,手术制备各组大鼠大脑中动脉闭塞(MCAO)模型,造成局灶性脑缺血,对脑部进行磁共振(MRI)扫描,观察预防性给予叶酸及其联合VB6及VB12,对缺血半暗带区的改善效果。结果 缺血后6 h,半暗带区表观弥散系数(ADC):MCAO+FA组为0.61±0.04,MCAO+CV组为0.63±0.04,均高于MCAO组的0.50±0.05(P<0.05),2组平均弥散系数(DCavg)依次为0.74±0.04,0.77±0.06,均高于MCAO组的0.67±0.04(P<0.05),MCAO组部分各向异性值(FA)为0.80±0.06,高于MCAO组的0.62±0.04(P<0.05)。结论 补充叶酸能使脑缺血半暗带区向正常灌注区发展,抑制缺血核心区的扩大,联合补充VB6和VB12效果更佳。

     

    Abstract: Objective To investigate the effects of folic acid,vitam in B6 and vitam in B12 on ischem is penumbra in focal cerebral ischemia rats.Methods Sprague-Dawley rats were randomly divided into three groups of MCAO model group (MCAO),MCAO+folic acid group (MCAO+FA)and MCAO+compound vitamins (folic acid+vitam in B6+vitam in B12)group (MCAO+CV).Middle cerebral artery occlusionmodelwas induced by operation Then all rats received magnetic resonance in aging (MRI) brain scan.Results Apparent diffusion coefficients (ADC) in MCAO+FA (0.61±0.04) and MCAO+CV (0.63±0.04) group were significantly higher than that of in MCAO group (0.50±0.05,P<0.05).Aavemge diffusion coefficients (DCavg) in MCAO+FA (0.74±0.04) and MCAO+CV group (0.77±0.06) were also higher than that of in MCAO group (0.67±0.04) (P<0.05).Fractional anisotropy (FA)in MCAO+CV group (0.80±0.06) was significantly higher than that of in MCAO group (0.62±0.04,P<0.05).Conclusion Supplement of folic acid can inhibit the extend of ischem is core Simultaneous adm inistration of vitam in B6 and vitam in B12 shows an additive effect.

     

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