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王齐, 赵焕虎, 陈建伟, 谷康定, 朱业湘, 郝巧玲, 张裕增, 周宜开, 叶临湘. 铅暴露对6~12岁儿童健康状况影响[J]. 中国公共卫生, 2009, 25(3): 339-341. DOI: 10.11847/zgggws2009-25-03-45
引用本文: 王齐, 赵焕虎, 陈建伟, 谷康定, 朱业湘, 郝巧玲, 张裕增, 周宜开, 叶临湘. 铅暴露对6~12岁儿童健康状况影响[J]. 中国公共卫生, 2009, 25(3): 339-341. DOI: 10.11847/zgggws2009-25-03-45
WANG Qi, ZHAO Huan-hu, CHEN Jian-wei, . Study on health effect of environmental lead exposure in children[J]. Chinese Journal of Public Health, 2009, 25(3): 339-341. DOI: 10.11847/zgggws2009-25-03-45
Citation: WANG Qi, ZHAO Huan-hu, CHEN Jian-wei, . Study on health effect of environmental lead exposure in children[J]. Chinese Journal of Public Health, 2009, 25(3): 339-341. DOI: 10.11847/zgggws2009-25-03-45

铅暴露对6~12岁儿童健康状况影响

Study on health effect of environmental lead exposure in children

  • 摘要: 目的 探讨南方某地6~12岁儿童铅暴露对健康损害状况。方法 采用分层随机抽样方法,选择某地6~12岁儿童进行问卷调查、健康体检、智力测试、Conners行为测试;采集儿童血、尿样,检测血铅浓度,全血锌原卟啉(ZPP)、尿δ-氨基-γ-酮戊酸(ALA)含量及血δ-氨基-γ-酮戊酸脱氢酶(ALAD)活性。结果 309名儿童血铅浓度几何均值为71.2μg/L,ZPP 0.15μg/g·Hb ,ALA24.4μg/L,ALAD活性328.9 U。54(17.5%)名儿童血铅≥100μg/L。血铅<100μg/L儿童ZPP与血铅呈负相关(r=-0.240),≥100μg/L儿童ZPP与血铅呈正相关(r=0.403)。ALAD与血铅呈负相关(r=-0.287)。血铅≥100μg/L儿童存在一定行为改变,身高、免疫力及智力水平低于血铅<100μg/L儿童。结论 该地儿童的铅暴露使体内相关酶含量、活性改变,且与儿童身高发育、免疫力、智力水平下降及行为改变有关。

     

    Abstract: Objective To explore the health impairments of environmental lead exposure in children of 6-12 years old.Methods Stratified random sampling was used.Questionnaire survey,physical examinations and intelligence examinations with Ravens' Standard Progressive Matrices were carried out among the children selected.Simplified Conners' Rating Scales(for teachers)was applied to assess the childrens' behavior.Blood and urine samples of the children were collected to determine the blood lead levels(BLLs),zinc protoporphyrin(ZPP)concentrations,δ-am inolevulinic acid dehydratase (ALAD)activities and urine δ-am ino-γ-levulinic acid(ALA)content.Results The geometric means of the children's BLLs,ZPP and ALA contents and ALAD activities was 71.2 μg/L,0.15 μg/g·Hb and 24.4 μg/L and 328.9 U,respectively.Fifty four(17.5%)children had BLLs ≥100 μg/L.The ZPP concentrations correlated with BLLs negatively as BLL s<100 μg/L,while positively as≥100 μg/L.The ALAD activities correlated with BLL spositively.Compared to children with BLLs<100 μg/L,children with BLLs ≥100 μg/L showed a decreased mimunity,lower intelligence and height,as well as behavioral changes.Conclusion Lead exposure is correlated with decreased heights,mimunity and in telligence,as well as behavioral changes among exposed chidren.

     

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