慢性铅中毒性肾损害患者EDTA驱铅效果分析

苏素花; 廖瑞庆; 农康; 葛宪民; 蒋东方; 韦国铭

doi:10.11847/zgggws2009-25-04-40

慢性铅中毒性肾损害患者EDTA驱铅效果分析

Curative effect of EDTA on kidney injury caused by chronic lead poisoning

摘要

摘要: 目的探讨依地酸钙钠(EDTA)驱铅治疗慢性铅中毒患者肾损害的保护作用。方法对52例慢性轻度铅中毒者连续3年用EDTA驱铅治疗,并对其进行血铅(PbB)、红细胞锌卟啉(ZPP)、尿β₂-微球蛋白(U-β₂-MG)、尿视黄醇结合蛋白(U-RBP)、尿N-乙酰-β-D-氨基葡萄糖苷酶(U-NAG)监测。结果慢性铅中毒患者PbB、ZPP、U-β₂-MG、U-NAG、U-RBP分别为(595.36±134.34)μg/L、(4.16±1.96)μmol/L、(564.02±224.32)μg/(g·Cr)、(31.91±13.37)U/(g·Cr)、(584.38±238.82)μg/(g·Cr)均显著高于对照组〔分别为(123.53±49.14)μg/L、(1.33±0.99)μmol/L、(139.26±66.62)μg/(g·Cr)、(11.83±3.7)U/(g·Cr)、(158.7±61.5)μg/(g·Cr)〕(P<0.01);连续3年用EDTA驱铅治疗后,U-β₂-MG、U-NAG、U-RBP逐年下降,不同时间比较其检测结果差异有统计学意义(P<0.01)。结论用EDTA驱铅治疗可逆转慢性铅中毒患者的肾损害。

Abstract: ObjectiveTo study the protective effect of sodium calcium edetate(EDTA)on kidney injury in chronic lead poisoning patients.MethodsThe 52 chronic lead poisoning workers were treated with EDTA for 3 years.The blood lead(PbB),erythrocyte zinc protoporphyrin(ZPP),urine β₂-microglobulin(U-β₂-MG),urine retinal conjugated protein(U-RBP),urine β-N-acetylyluco-samidase(U-NAG)of the workers were dynamically detected.ResultsAll of the indices of poisoning worker were higher than that of control group before EDTA treatment(P<0.01).After continuously treatment of EDTA,the values of the indices decreased year by year and the differences in the values between each year were significant(P<0.01).ConclusionThe EDTA treatment is protective to the kidney injury in chronic lead poisoning patients.

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