Abstract: Objective To analyze the status and problems of infectious disease prevention among floating population in Hongkou district for the improvement of the disease management model.Methods Epidemic data analysis,questionnaire survey,interview,document study were adopted.Results The incidence rate of infectious disease in floating population of the district descended from 836.30/105 (year 2002) to 167.92/105 (year 2007)with an annual incident rate of 355.60/105 which was significantly higher than that of local population (χ²=656.54,P<0.01).Floating population had much lower knowledge of infectious disease control and prevention than that of local population (P<0.01).There existed defects in infecous disease management in floating population.Conclusion The epidemic of infecfious disease among floating population in Shanghai showed a descendent trend in the past five years.The floating population have little knowledge of infectious disease control and prevention.