Abstract: Objective To explore the jointe ffects of nutrients against the toxicity of lead.Methods With self-com parison and group-comparison design,six nutrients were tested in a clinical intervention trial.The nutrients were vitam in C, vitam in B₁,calcium,iron,zinc,selenium,which have effects of against lead toxicity.Results On the avrage,the nutrients could reduce blood lead from 160.4±29.2 μg/L to 125.8±20.1 μg/L and increase urine lead from 30.4±815 μg/L to 39.6±11.6 μg/L in the experimental group.After the experiment,the experimental group showed significant differences compared with itself and the control group in the descent of blood lead and the elmiination of urine lead(P < 0.01).The elmiination ratio of urine lead was higher than that of urine calcium and urine zinc in the expermiental group on the same tmie point(P < 0.05).The nutrients relieved clinical symptoms of the patients(P < 0.05).Conclusion The joint effects of nutrients against lead poisoning could be achieved by jointadm in istration in children.