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张明, 娄培安, 刘林, 陈培培, 张亚, 刘杰, 李军政. 耐多药肺结核患者耐药情况及影响因素[J]. 中国公共卫生, 2010, 26(11): 1439-1440. DOI: 10.11847/zgggws2010-26-11-51
引用本文: 张明, 娄培安, 刘林, 陈培培, 张亚, 刘杰, 李军政. 耐多药肺结核患者耐药情况及影响因素[J]. 中国公共卫生, 2010, 26(11): 1439-1440. DOI: 10.11847/zgggws2010-26-11-51
ZHANG Ming, LOU Pei-an, LIU Lin, . Drug resistance and its influencing factors among patients with multidrug-resistant tuberculosis[J]. Chinese Journal of Public Health, 2010, 26(11): 1439-1440. DOI: 10.11847/zgggws2010-26-11-51
Citation: ZHANG Ming, LOU Pei-an, LIU Lin, . Drug resistance and its influencing factors among patients with multidrug-resistant tuberculosis[J]. Chinese Journal of Public Health, 2010, 26(11): 1439-1440. DOI: 10.11847/zgggws2010-26-11-51

耐多药肺结核患者耐药情况及影响因素

Drug resistance and its influencing factors among patients with multidrug-resistant tuberculosis

  • 摘要: 目的探讨耐多药肺结核(MDR-TB)患者的成因。方法对结核菌药敏试验阳性的100例MDR-TB患者进行耐药现状、抗结核治疗情况、肺部病变及合并症分析。结果 100例MDR-TB患者中,96例(96.0%)患者未按照早期、联合、适量、规律、全程的肺结核治疗原则治疗,耐多药者男性85例,多于女性的15例,>60岁老人占51.0%。耐≥3种抗结核药物的患者占92.0%;MDR-TB发生与性别、文化程度、人均收入、年龄、结核病治疗史有关。结论 MDR-TB发生主要与患者不规则治疗有关,同时受性别、文化程度、人均收入、年龄、结核病治疗史的影响。

     

    Abstract: ObjectiveTo investigate the status of drug resistance and its influencing factors among patients with multidrug resistant tuberculosis(MDR-TB).MethodsThe status of drug resistance,treatment of tuberculosis,lung lesions and complications of 100 MDR-TB patients were analyzed with TB drug susceptibility test.ResultsOf all MDR-TB patients, 96(96.0%)did not follow the principle of TB treatment(early,joint,adequate,regular and full treatment).Among the patients,there were 85 men and 15 women with 51.0% of patients more than 60 years old.There were 92.0% of the patients with resistance to three kinds of anti-TB drug and 43.0% of them with complications.Sex,educational level,per capita income,age,history of the tuberculosis treatment were associated with MDR-TB.ConclusionThe incidence of MDR-TB is associated with irregular treatment,as well as with gender,educational level,per capita income,age,history of tuberculosis treatment.

     

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