Abstract: ObjectiveTo study changes of serum prote in Z(PZ)and high sensitive Creactive prote in(hsCRP)and its clinical significance among pregnant wonen with pregnancy-induced hypertention.MethodsThe serum PZ and hsCRP were determined among early,mid-,late,and delivery pregnant women with pregnancy-induced hypertension and normal pregnant women(control)and the differences between the two groups were analyzed.ResultsCompared with the control group,the contents of serum PZ and hsCRP among the pregnant women with pregnancy-induced hypertention were significantly different(P<0.05 or P<0.01).The serum PZ contents for women with light, mode rate,and severe hypertension were 162±0.41,1.38±0.32,and 1.16±0.26 mg/L,and the serum hsCRP contents were 3.69±0.33,3.90±0.37,and 4.16±0.41 mg/L.The serum PZ and hsCRP was negatively correlated among the hypertensive pregnant women at different periods of pregnancy(r=-0.795,P<0.01)and with different levels of blood pressure(r=-0.799,P<0.01).ConclusionThe decrease of serum PZ and the increase of hsCRP can lead to high blood pressure among pregnan twomen.Detection of maternal serum PZ and hsCRPis helpful to prevention and treatment of pregnancy-induced hypertension.