Abstract: Objective To investigate interactive effect of vitam in D receptor(VDR) gene polymorphism and environment factors on physical development among adolescents.Methods To tally 212 adolescents at age of 17 to 18 years were randomly selected from senior high schools of Shaoxing city for physical examination and questionnaire survey.Polym erase chain reaction(PCR) and DNA sequencing were performed to analyze the VDR genotype.There lationship between VDR gene polymorphism and environmental factors on physical development was analyzed with ordinal logistic regression analysis.Results The results showed that the interactive effect existed in BsmI gene site polymorphism and physical exercise with an interaction index value of 3.208.The in teractive effect existed in Tru9I gene site polymorphism and physical exercise,sleeping tmie,the importance of physical exercise advocated by the school with the interaction index value of 2.499,1.936,and 1.987,respectively.Conclusion VDR gene polymorphism and environment factors show an interactive effect on physical development among adole scents.