Abstract: Objective To investigate the influencing factors of hospitalization expenditure among patients with chronic hepatitis B(CHB) related diseases,and to provide evidence for the improvement of medicine security system and CHB prevention.Methods The medical records of patients with CHB related diseases in general hospital of Shanxi province from 2002 to 2009 were collected.Principal component analysis and multivariate Coxreg ression model were applied in the analysis.Results From 2002 to 2009,the number of inpatients with CHB related diseases increased yearly.The average age of the inpatients was 46.5±13.93 years and 60.02 percent of the patients were farmers.The average tmie of hospitalization was 16 days.The significant influencing factors of the hospitalization expenditure included admission state,secondary diagnosis,hospitalization days,status of HBsAg,proportion of medicine cost,and age(P < 0.01 for all).Conclusion The economic burden of patients with CHB related diseases were heavier.We should streng then hospital management and establish clinical practice guideline and criteria for the control of proportion of medicine cost and days of hospitalization to decrease the economic burden of the patients.