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陈静, 黄文湧, 杨敬源, 杨星, 汪俊华, 蔡毅媛, 韦继芳. 老年人轻度认知功能损害与ApoE基因多态性关系[J]. 中国公共卫生, 2011, 27(7): 836-838. DOI: 10.11847/zgggws2011-27-07-10
引用本文: 陈静, 黄文湧, 杨敬源, 杨星, 汪俊华, 蔡毅媛, 韦继芳. 老年人轻度认知功能损害与ApoE基因多态性关系[J]. 中国公共卫生, 2011, 27(7): 836-838. DOI: 10.11847/zgggws2011-27-07-10
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CHEN Jing, HUANG Wen-yong, YANG Jing-yuan, . Relationship between Apo E gene polymorphism and risk of different subtypes of mild cognitive impairment[J]. Chinese Journal of Public Health, 2011, 27(7): 836-838. DOI: 10.11847/zgggws2011-27-07-10
Citation: CHEN Jing, HUANG Wen-yong, YANG Jing-yuan, . Relationship between Apo E gene polymorphism and risk of different subtypes of mild cognitive impairment[J]. Chinese Journal of Public Health, 2011, 27(7): 836-838. DOI: 10.11847/zgggws2011-27-07-10
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老年人轻度认知功能损害与ApoE基因多态性关系

Relationship between Apo E gene polymorphism and risk of different subtypes of mild cognitive impairment

    摘要
  • 摘要: 目的 探讨社区老年人轻度认知功能损害(MCI)及其亚型发病与Apo E基因多态性的关系。方法 对贵州省贵阳市城区≥60岁认知功能正常老年人2 207名随访3年后,选择新发MCI患者和相应对照进行1:2匹配巢式病例对照研究;Apo E等位基因分型测定采用限制性片段长度多态性分析技术(RFLP-PCR);采用COX模型拟合条件Logistic回归分析法进行影响因素分析。结果 MCI新发病例105例,发病密度为18.2/千人年;其中遗忘型发病密度为12.9/千人年;非遗忘型发病密度为5.4/千人年;单因素分析显示,携带Apo Eε4基因是未分型MCI和遗忘型MCI发病的共同危险因素(OR=2.463,95%CI=1.372～4.433;OR=2.824,95%CI=1.375～5.876),携带Apo Eε2基因是非遗忘型MCI发病的危险因素(OR=3.688,95%CI=1.140～11.930);而携带Apo Eε3基因可降低未分型MCI及非遗忘型MCI的发病风险(OR=0.478,95%CI=0.275～0.864;OR=0.380,95%CI=0.147～0.984);控制受教育程度及相关血脂因素后,携带Apo Eε4基因仍然是老年人发生MCI尤其是遗忘型MCI的危险因素(未分型OR=2.686,95%CI=1.407～5.127;遗忘型OR=2.743,95%CI=1.260～5.970);对非遗忘型MCI有影响的Apo E基因亚型仅为ε3型(OR=0.305,95%CI=0.103～0.899)。结论 Apo E基因多态性对社区老年人群MCI及其不同亚型发病的影响可能存在一定差异。携带Apo Eε4基因是未分型MCI和遗忘型MCI发病共同的独立危险因素,而ApoEε3基因可能防止非遗忘型MCI的发生。

     

    Abstract: Objective To explore the relationship between Apo E gene polymorphism and the risk of mild cognitive impairment(MCI) and its subtypes among the community elderly population.Methods A 1:2 matched nested case-control studyas conducted on the basis of a cohort of 2 207 individuals aged 60 and overith normal cognitive function in Guiyang city.According to the results of mini-mental state examination(MMSE) screening,the subjectsere selected based on the outcome at the end of a 3 years follow-up.All of the subjectsere genotyped for Apo Eith restriction fragment length polymorphism(RFLP)-PCR.The dataas analyzed by using fitted conditional logistic regressionith Cox regression model.Results During the 3 years follow-up,105 new cases of MCIere diagnosedith an estimated incidence density of 18.2 per 1 000 person-years.The cases included 74 amnestic MCIith an estimated incidence density of 12.9 per 1 000 person-years,and 31 non-amnestic MCIith an estimated incidence density of 5.4 per 1 000 person-years.Single-factor analysis showed that Apo E ε4 geneas a common risk factor to the incidence of total MCI and amnestic MCI(odds ratioOR=2.463,95% confidence intervalCI:1.372-4.433; OR=2.824,95% CI:1.375-5.876).Apo E ε2 gene increased the risk of non-amnestic MCI(OR=3.688,95% CI:1.140-11.930).While Apo E ε3 gene might reduce the incidence of non-amnestic MCI and total MCI(OR=0.478,95% CI:0.275-0.864; OR=0.380,95% CI:0.147-0.984).After adjustment for education and relevant vascular risk factors,Apo E ε4 alleleas still related to a significantly higher risk of total MCI,especially amnestic MCI(OR=2.686,95% CI:1.407-5.127; OR=2.743,95% CI:1.260-5.970).However,non-amnestic MCIas associatedith Apo E ε3 allele(OR=0.305,95% CI:0.103-0.899).Conclusion Apo E gene polymorphism had different effects on the incidence of subtypes of MCI among the elderly in community.Apo E ε4 gene is a common independent risk factor for total MCI and amnestic MCI.Conversely,Apo E ε3 allele may have protective effect on the occurrence of non-amnestic MCI.

     

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