Abstract: Objective To examine acute stress reaction among the injured persons after Yushu earthquake for early and effective psychological intervention.Methods A face-to-face interview was carried out among 90 injured persons with the Post-Traumatic Stress Disorder Symptoms Civilian Version (PCL-C) within three days after Yushu earthquake in 2010.Results The total score of PCL-C ranged from 18 to 74 among the injuries with an average score of 43±13.89.A total of 28 injuries (31.11%) were positive for PTSD and 62 (68.89%) were negative.The most common symptom was re-experience(87.78%),follow ed by high alert(67.77%),and avoiding numbness(33.33%).Conclusion There was a high incidence of acute stress reaction among the injuries of Yushu earthquake and it is important to take timely and effective psychological intervention.