Abstract: Objective To study related factors of hepatocellular carcinoma in population of Qingdao city and to provide scientific basis for control and prevention of hepatocellular carcinoma.Methods A case-control study involving 194 hepatocellular carcinoma cases and 210 age-,community-matched health controls was carried out.The main related factors were analyzed with logistic regression model and evaluated by odds ratio(OR) and 95% confidence interval(95% CI).Results Single factor analyses showed that hepatits B surface antigen(HBsAg) positive,personal history of hepatitis,family history of liver cancer,and intake of fat and smoked food were the main risk factors of hepatocellular carcinoma.But intakes of fresh fish,garlic and onion,tea,outgoing personality and happiness were the protective factors.Multiple factor analyses showed that HBsAg positive(OR=23.370,95% CI:12.625-43.258),personal history of hepatitis(OR=5.188,95% CI:1.888-14.258),intake of smoked food(OR=3.082,95% CI:1.469-6.467),and intake of fat(OR=2.685,95% CI:1.458-4.943) were the main risk factors of hepatocellular carcinoma.But drinking tea(OR=0.533,95% CI:0.292-0.973),taking fresh fish(OR=0.448,95% CI:0.224-0.895),and happiness(OR=0.305,95% CI:0.131-0.713) were the protective factors.Conclusion HBsAg positive,personal history of hepatitis,intakes of smoked food and fat may be the main risk factors of hepatocellular carcinoma,whereas,consumption of tea and fresh fish and happiness may be the proctective factors.