Abstract: ObjectiveTo investigate the quality of life and its influencing factors among chronic hepatitis B patients.MethodsWith stratified cluster sampling method,from March to September 2010,636 patients from six general hospitals in Ningxia were selected to participate in the survey and were evaluated with the MDS 36-Item Short Form Health Survey (SF-36).The data were analyzed with SPSS11.5 statistical software.Resultscompared with the domestic norm,the scores of the chronic hepatitis B patients'role physical(15.6±35.1),body pain(59.2±16.7),general health (37.5±20.9),social functioning(64.0±26.0),and role emotional(19.0±37.6)were lower(P<0.05).The patients' quality of life had significant differences in gender and age(P<0.05).The age,gender,ethnics were influencing factors of the quality of life of the chronic hepatitis B patients base on logistic analysis.In addition,the age,complications,gender were influencing factors of physical function and smoking,age,medical insurance were influencing factors of mental health.ConclusionThe quality of life for patients with chronic hepatitis B is lower than healthy people and affected by many factors.