Abstract: ObjectiveTo investigate immunoregulation functions of millet polypeptides in mice.MethodsTotally 160 healthy mice were randomly divided into 4 groups and were orally administered with millet polypeptides at the doses of 250,500,and 1 000 mg/kg·d for 30 days,respectively.Lymphocyte transformation test,determination of 50% haemolysis concentration(HC₅₀),phagocytic function of macrophage,and immune organ index were determined.ResultsDifferent dose of millet polypeptides could enhance lymphocyte transformation.The phagocytic percentage in the mice of 500,1 000 mg/kg·d millet peptides group were 59.45±5.16%,65.7±4.31% ;the phagocytic index were 0.83±0.11,0.88±0.09;HC₅₀ were 171.33±8.77,175.91±9.22.The millet polypeptides treatment group had significant differences in spleen index and thymas index compared with the control group(P<0.01).ConclusionMillet polypeptides exhibit a significant effect on improvement of immune functions in mice.