Abstract: Objective To study epidemiological distribution of sub-health and its influencing factors among medical college students.Methods With random stratified and clustered sampling,1 581 students in Chengde Medical College were selected and investigated on their sub-health status and influencing factors,including age,gender,grade and specialty,study load,family monthly income,and physical exercise.Results The prevalence rate of total sub-health was 69.2%.The prevalence rate of physical,mental,and social sub-health were 39.6%,52.6%,and 48.3%.The prevalence rates of physical sub-health was significantly different between the students of different age(P < 0.05).The prevalence rate of total subhealth was not significantly different among the students of different gender,family monthly income,and birth place(P >0.05).The prevalence rates of physical,social,and total sub-health were significantly different among the students with different specialty(P < 0.05).The prevalence rate of physical,mental,and social sub-health of the students with diffenrent study load,physical exercise,and grades were significantly different(P < 0.05).Conclusion The prevalence of sub-health among medical college students is high and mainly affected by grade,specialty,study load,and physical exercise.