高级检索

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

成骨细胞特异性转录因子Osterix研究进展

杨丹 于燕妮

杨丹, 于燕妮. 成骨细胞特异性转录因子Osterix研究进展[J]. 中国公共卫生, 2013, 29(1): 142-145. doi: 10.11847/zgggws2013-29-01-49
引用本文: 杨丹, 于燕妮. 成骨细胞特异性转录因子Osterix研究进展[J]. 中国公共卫生, 2013, 29(1): 142-145. doi: 10.11847/zgggws2013-29-01-49

成骨细胞特异性转录因子Osterix研究进展

doi: 10.11847/zgggws2013-29-01-49
基金项目: 

国家科技部国际合作重点项目(2010DEF30530);贵阳市科学技术项目(2009筑科农合同字第3-007)

详细信息
    作者简介:

    杨丹(1984- ),女,贵州贵阳人,硕士在读,主要从事氟中毒研究工作。

    通讯作者:

    于燕妮,E-mail:yuyanni@gmc.edu.cn

  • 中图分类号: R361

  • [1] Nakashima K,Xin Z,Kunkel G,et al.The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation[J].Cell,2002,108(1):17-29.
    [2] Ohyama Y,Nifuji A,Maeda Y,et al.Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis[J].Endocrinology,2004,145(10):4685-4692.
    [3] Nakashima K,de Crombrugghe B.Transcriptional mechanisms in osteoblast differentiation and bone formation[J].Trends Genet,2003,19(8):458-466.
    [4] Huang L,Teng XY,Cheng YY,et al.Expression of preosteoblast markers and Cbfa-1 and Osterix gene transcripts in stromal tumour cells of giant cell tumour of bone[J].Bone,2004,34(3):393-401.
    [5] 程敏,李祥伟,苗雷英,等.人牙发育中OSX 的表达[J].口腔医学研究,2006,22(4):372-375.
    [6] Cao Y,Zhou Z,De Crombrugghe B,et al.Osterix,a transcription factor for osteoblast differentiation,mediates antitumor activity in murine osteosarcoma[J].Cancer Res,2005,65(4):1124-1128.
    [7] Tai G,Polak JM,Bishop AE,et al.Differentation of osteoblasts from murine embryonic stem cells by overexpression of the transcriptional factor osterix[J].Tissue Eng,2004,10(9-10):1456-1466.
    [8] Amorim BR,Okamura H,Yoshida K,et al.The transcriptional factor osterix directly interacts with RNA helicase A[J].Biochem Biophys Res Commun,2007,355(2):347-351.
    [9] Koga T,Matsui Y,Asagiri M,et al.NFAT and Osterix cooperatively regulate bone formation[J].Nat Med,2005,11(8):880-885.
    [10] Winslow MM,Pan M,Starbuck M,et al.Calcineurin/NFAT signaling in osteoblasts regulates bone mass[J].Cell,2006,10(6):771-782.
    [11] Pereira RC,Durant D,Canalis E.Transcriptional regulation of connective tissue growth factor by cortiosol in osteoblasts[J].Am J Physiol Endocrinol Metab,2000,279(3):570-576.
    [12] Xu J,Smock SL,Safadi FF,et al.Cloning the full-length cDNA for rat connective tissue growth factor:implications for skeletal development[J].J Cell Biol Chem,2000,77(1):103-115.
    [13] Goppelt-Struebe M,Hahn A,Iwanciw D,et al.Regulation of connective tissue growth factor(ccn2,cgtf) gene expression in human mesangial cells:modulation by HMG CoA reductase inhibitors(statins)[J].J Clin Pathol Mol Pathol,2001,54(3):176-179.
    [14] Lee MH,Kwon TG,Park HS,et al.BMP-2-induced osterix expression is mediated by Dlx5 but is independent of Runx2[J].Biochem Biophys Res Commun,2003,309(3):689-694.
    [15] 孙冬梅,刘中博,赵岩,等.Runx2参与调控Osterix启动子活性及其基因表达[J].生物化学与生物物理进展,2006,33(10):957-964.
    [16] Komori T.Regulation of osteoblast differentiation by transcription factors[J].J Cell Biochem,2006,99(5):1233-1239.
    [17] Matsubara T,Kida K,Yamaguchi A,et al.BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation[J].J Biol Chem,2008,283(43):29119-29125.
    [18] Celil AB,Hollinger JO,Campbell PG.OSX transcriptional regulation is mediated by additional pathways to BMP2/Smad signaling[J].J Cell Biochem,2005,95(3):518-528.
    [19] Celil AB,Campbell PG.BMP-2 and insulin-like growth factor-I mediate Osterix(OSX) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways[J].J Biol Chem,2005,280(36):31353-31359.
    [20] Wang X,Goh CH,Li B.p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterix[J].Endocrinology,2007,148(4):1629-1637.
    [21] Lee MH,Kwon TG,Park HS,et al.BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2[J].Biochem Biophys Res Commun,2003,309(3):689-694.
    [22] 潘秋辉,李益广,杨松海,等.骨形态发生蛋白2通过Smad途径上调Osterix的表达[J].中国生物化学与分子生物学报,2008,24(1):40-45.
    [23] Bennett CN,Longo KA,Wright WS,et al.Regulation of osteoblastogenesis and bone mass by Wnt10b[J].Proc Natl Acad Sci USA,2005,102(9):3324-3329.
    [24] Maehata Y,Takamiazwa S,Ozawa S,et al.Both direct and collagen-mediated signals are required for active vitamin D3-elicited differentiation of human osteoblastic cell:roles of osterix,an osteoblast-related transcription factor[J].Matrix Biol,2006,25(1):47-58.
    [25] Xing W,Singgih A,Kapoor A,et al.Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells[J].J Biol Chem,2007,282(30):22052-22061.
    [26] Lu X,Gilbert L,He X,et al.Transcriptional regulation of the osterix(OSX,Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways[J].J Biol Chem,2006,281(10):6297-6306.
    [27] Zambetti GP,Horwitz EM,Schipani E.Skeletons in the p53 tumor suppressor closet:genetic evidence that p53 blocks bone differentiation and development[J].J Biol,2006,172(6):795-797.
    [28] Hong SH,Lu X,Nanes MS,et al.Regulation of osterix(OSX,Sp7) and the OSX promoter by parathyroid hormone in osteoblasts[J].J Mol Endocrinol,2009,43(5):197-207.
    [29] Kaback LA,Soung do Y,Naik A,et al.Teriparatide(1-34 human PTH) regulation of osterix during fracture repair[J].J Cell Biochem,2008,105(1):219-226.
    [30] Yu S,Franceschi RT,Luo M,et al.Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone[J].PLoS One,2009,4(10):e7583.
    [31] 张亚楼,刘开泰,刘继文,等.氟对成骨细胞Runx2 和Osterix 及COLⅠA2表达的影响[J].中国地方病学杂志,2011,30(1):23-26.
    [32] 郭敏锋,孙海飚,刘强.P物质在成骨细胞分化过程中对转录因子Osterix表达的影响[J].第四军医大学学报,2009,30(5):421-434.
    [33] 马信龙,刘泽朋,马剑雄,等.激素性股骨头坏死股骨头内Runx2、Osterix及AJl 8的动态表达[J].中华骨科学杂志,2010,30(1):67-72.
    [34] 李淑梅,宋利格,张秀珍.淫羊藿苷对大鼠成骨细胞功能及Osterix表达的影响[J].同济大学学报:医学版,2005,26(6):8-11.
    [35] Cao Y,Zhou Z,de Crombrugghe B,et al.Osterix,a transcription factor for osteoblast differentiation,mediates antitumor activity in murine osteosarcoma[J].Cancer Res,2005,65(4):1124-1128.
    [36] Xu B,Zhang J,Brewer E,et al.Osterix enhances BMSC-associated osseointegration of implants[J].J Dent Res,2009,88(11):1003-1007.
    [37] Lapunzina P,Aglan M,Temtamy S,et al.Identification of a frameshift mutation in osterix in a patient with recessive osteogenesis imperfecta[J].Am J Hum Genet,2010,87(1):110-114.
  • 加载中
计量
  • 文章访问数:  940
  • HTML全文浏览量:  135
  • PDF下载量:  33651
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-03-28
  • 刊出日期:  2013-01-10

目录

    /

    返回文章
    返回