Abstract: Objective To explore the susceptibility of lung cancer in relation to CYP1A1 Exon7 and GSTP1 genetic polymorphisms.Methods CYP1A1 Exon7 and GSTP1 genetic polymorphisms were determined by allele specific amplification(ASA) in 116 lung cancer patients and 216 healthy controls.Results The individuals who carried with CYP1A1 Exon 7 mutant heterozygote and homozygote had a high risk of lung cancer.However,the GSTP1 mutant heterozygote and homozygote were protective factors of lung cancer.The susceptibility to lung cancer associated with CYP1A1 Exon 7 and GSTP1 was not observed.The combined CYP1A1 mutant genotype and smoking were found to be significant risk factors of lung cancer,but not for GSTP1.Conclusion The polymorphisms of CYP1A1 Exon 7 mutant genotype maybe are the suspicious risk factors for lung cancer.The polymorphisms of GSTP1 mutant genotype might reduce the risk of lung cancer.Smoking is a susceptibility factor of lung cancer.There may be no association of CYP1A1 and GSTP1 with susceptibility to lung cancer.The combination of CYP1A1 Exon 7 mutant genotype and smoking could increase the risk of lung cancer,but the polymorphisms of GSTP1 mutant genotype and smoking may reduce the risk of lung cancer.