Abstract: Objective To investigate the relationship between plasma high-sensitivity C-reactive protein(Hs-CRP) and traditional cardiovascular risk factors in the island residents.Methods Totally 395residents of Changhai county,Dalian city,were selected for the survey.We assessed the relationship between Hs-CRP and cardiovascular risk factors,such as age,blood pressure,smoking status and serum lipids.The data were analyzed with SPSS 16.0 statistical package.Results Plasma Hs-CRP level was 0.11 mg/l in the subjects.Plasma Hs-CRP positively correlated with age,waist circumference,body mass index,fasting blood glucose,cholesterol,triglycerides,low-density lipoprotein cholesterol,creatinine,and uric acid,with the correlation coefficients of 0.26,0.32,0.30,0.18,0.28,0.21,0.29,0.11,0.21,and 0.21,respectively.The high-density lipoprotein cholesterol and Hs-CRP showed a inverse correlation.In multiple regression analyses,fasting blood glucose,body mass index,age,high-density lipoprotein cholesterol,serum cholesterol,and smoking showed independent correlation with plasma Hs-CRP.Conclusion Hs-CRP level is affected by body mass index,age,fasting blood glucose,and high-density lipoprotein cholesterol and smoking status in the island residents.Weight control,reducing obesity could maintain the serum Hs-CRP within the normal level.