Abstract: Objective To examine hypertension-related knowledge and its influencing factors among residents in Nantong city.Methods Totally 1 500 residents over age of 18 years in Nantong city were selected with stratified cluster sampling in July 2010 and investigated on hypertension-related knowledge with a questionnaire.Results The overall rate of hypertension-related knowledge was 32.83%(35.91% in male and 31.80% in female).The awares rate was 33.56% for measuring blood pressure at least one time a year after the age of 35 years,46.34% for diagnostic criteria of hypertension,62.03% for risk factors,60.08% for complications,and 34.32% for treatment of hypertension,respectively.Multi-variate logistic analysis showed that the influencing factors of the hypertension-related kngwledge were age,education,marital status,occupation,and pattern of physical excercise.Conclusion The hypertension-related knowledge is poor in residents of Nantong,especially for residents with low education and living in rural areas.