Abstract: Objective To analyze the association of adipocytokines with insulin resistance(IR)and obesity.Methods Using simple cluster random sampling method,6 918 Korean and Han people residing in rural area of Yanbian city were selected and investigated with a questionnaire survey and physical examination.Results The level of adiponctin was higher in Han-Chinese than that in Korean-Chinese,and the levels of leptin (only for males),tumor necrosis factor-alpha(TNF-α),homeostasis model assessment-insulin resistance(HOMA-IR),waist circumference(WC)and body mass index(BMI)were higher in Korean-Chinese than those in Han-Chinese for both sexes (all P<0.001).The Results of partial correlation analysis showed that adiponectin was inversely related with HOMA-IR,WC and BMI,with the r values of-0.080,-0.238,and-0.280 (P<0.001 for all)and leptin (r=0.103,0.404 and 0.520;P<0.001)and TNF-α (r=0.192,0.898 and 0.692;P<0.001)were positively related with HOMA-IR,WC and BMI after adjustment for age,sex and race.The Results of multivariate regression analysis showed significant linear correlations between adiponectin (β'=-0.036,-0.062 and-0.224),leptin (β'=0.027,0.044 and 0.485),and TNF-α (β'=0.031,0.852 and 0.067)and HOMA-IR,WC,and BMI.Conclusion There are significant differences in the distributions of adiponectin,leptin and TNF-α between different ethnic group.HOMA-IR,WC and BMI have significant effects on adiponectin,leptin and TNF-α,and the affection of obesity is stronger than that of HOMA-IR.