Abstract: Objective To examine major lifestyle diseases and their main risk factors among rural redisents in Jinzhou city,Liaoning province.Methods Stratified random sampling was used and 918 residents aged between 20 to 70 years were investigated with a questionnaire survey and physical examination.Results The prevalence of lifestyle disease was 27.6%.The prevalence for male(55.3%)was higher than that for female(44.7%)(χ²=5.197,P=0.027).The prevalence of hypertension,diabetes mellitus,cerebral thrombosis,lumbar disc herniation,and obesity were 15.6%,4.0%,2.0%,3.6%,and 2.4%,respectively.With the increment of the age,the prevalence rate of lifestyle disease increased,with a statistically significant difference(χ²=87.129,P=0.000).The Results of logistic regression showed that smoking(odds ratio OR=1.250,95% confidence interval 95%CI=1.025-1.525),family smoking(OR=1.590,95%CI=1.053-2.403),alcohol use(OR=1.291,95%CI=1.048-1.591),consumption of pickle food(OR=1.200,95%CI=1.041-1.382),frequent consumption of potato food(OR=1.410,95%CI=1.177-1.690),and family history of lifestyle disease (OR=4.831,95%CI=2.636-8.853)were risk factors of lifestyle disease.Eating garlic frequently (OR=0.843,95%CI=0.734-0.969)and having suffecient sleep(OR=0.474,95%CI=0.374-0.599)were the protective factors.Conclusion Lifestyle disease among rural residents of Jinzhou is the result of affection of many factors and targeted preventive measures should be taken to promote the prevention of the diseases.