Abstract: ObjectiveTo explore the effect of water quality on obesity-related indicators in mice.MethodsThe water quality parameters were measured for tap water,pure water and high metasilicate mineral water,respectively,and the parameters included total dissolved solids(TDS),pH,oxidation reduction potential(ORP),electric conductivity(EC),metasilicic acid,calcium,and magnesium.Sixty ICR mice(half male and half female)were randomly divided into three groups and fed with tap water(control group),pure water,and mineral water,respectively.After 90 days,blood samples were taken from the eyeballs of the mice.The contents of serum total cholesteral(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),body weight,Lee's index,liver coefficient,and fat coefficient were evaluated.ResultsThe water quality parameters of the three kinds of water were diverse from each other(P<0.05).Compared with the control group,an increasing trend in body weight and Lee's index in pure water group was observed,and the serum TC(2.14±0.29 mmol/L)and LDL-C(0.22±0.032 mmol/L)in female mice decreased significantly(P<0.05).Compared with the control group,an increasing trend in serum HDL-C was observed in female mice of mineral water group,but other obesity-related indicators had a decreasing tendency,particularly a significant decline in serum LDL-C(0.23±0.031 mmol/L)was observed(P<0.05).In addition,a significant positive correlation emerged between the serum LDL-C and ORP in water(P<0.05) in the female mice.ConclusionWater quality may has biological effects on blood lipid metabolism in female mice,especially ORP.