Abstract: Objective To study epidemiological characteristics of families with human immunodeficiency virus(HIV)-infected adult members and immune status of the HIV-infected adults in Henan province.Methods Data on families with HIV-infected adult members were collected from AIDS-Infected Family Follow-up Management and Analysis System and Henan Province AIDS Data Analysis System and analyzed;the immune status of the adult HIV-infected members in the families was examined.Results There were 25 188 families with HIV-infected adults and 29 812 HIV-infected adults in the families in Henan province in 2011.The families with HIV-infected adults mainly distributed in the southeast area of Henan province.For the HIV-infected adults in the families,71.37%were at age of 35-54 years;83.90%(25 013/29 812)received antiretroviral therapy;84.82%(19 775/23 313) were infected through blood transmission, with a significant higher ratio than that infected through other routes(χ²=1 692.920, P=0.000).Of the HIV-infected adults,72.36%(21 573)had CD₄ T lymphocyte count,with a mean of 393 cells/μl and an interquartile range of 238-506 cells/μl;47.97%(14 302)had viral load test and those infected through sexual transmission had a higher viral load and a lower rate of antiretroviral therapy.Conclusion The number of families with adult HIV-infected members is large and most of the HIV-infected members are at the age of 35-54 years.The HIV-infected adults with sex transmission are a key population for treatment and aid.