Serum pertussis antibody among 0-6 years old children in Xinjiang
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摘要: 目的 了解新疆健康儿童百日咳抗体水平,为有效预防控制百日咳提供依据。方法 在新疆14个地州96个县(市、区)选择0~6岁健康儿童4354人,收集流行病学信息和采集血清标本,使用酶联免疫吸附试验(ELISA)检测百日咳IgG抗体。结果 新疆4354名0~6岁健康儿童中,百日咳抗体阳性688人,阳性率为15.80%(95%CI=14.72%~16.88%);百日咳抗体阳性率随年龄增加而增加,6岁组儿童抗体阳性率最高,阳性率为21.38%(95%CI=28.58%~40.24%);4剂次百白破疫苗接种史的儿童中,2009年以前出生的儿童其抗体阳性率明显高于2009年以后出生儿童。结论 新疆0~6岁儿童百日咳IgG抗体阳性率较低,儿童处于百日咳发病高危状态;无细胞百白破(DTaP)疫苗的百日咳免疫效果较全细胞百白破(DTwP)差。应尽快加强百白破疫苗中百日咳组分免疫原性的研究。Abstract: Objective To examine antibody level of pertussis among the healthy children in Xinjiang Uygur Autonomous Region(Xinjiang)and to provide evidences for pertussis prevention and control.Methods Totally 4354 healthy children aged 0-6 years were selected from 96 towns in 14 regions in Xinjiang.A questionnaire survey was conducted and blood samples were collected among the children.Serum immunoglobulin G(IgG)against pertussis was detected with enzyme-linked immunosorbent assay(ELISA).Results Among the children,665(15.80%,95%confidence interval[95%CI]:14.72%-16.88%)were pertussis IgG antibody positive;the positive rate increased with age and the children 6 years old had the highest positive rate (21.38%,95%CI:28.58%-40.24%).Among the children with 3 or 4 doses of diphtheria-tetanus-pertussis(DTP) vaccines,the IgG antibody positive rate for the children born before 2009 was significantly higher than those born after 2009.Conclusion The positive rate of IgG antibody against pertussis was very low for 0-6 years old children in Xinjiang,suggesting the children being under the high risk of pertussis.The immunogenicity of acellular DTP vaccine is lower than that of whole-cell DTP.The study on immunogenicity of pertussis vaccine component should be enhanced.
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