Variation tendency and epidemiologic characteristics of influenza in Liao-ning province,2010-2014
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摘要: 目的 了解2010-2014年度辽宁省流感流行趋势及病原谱,为流感的预防控制提供参考依据。方法 对2010-2014年21家流感监测哨点医院每周在监测科室监测到的流感样病例(简称ILI)、采集的ILI标本用MDCK细胞进行流感病毒分离后用血凝抑制试验进行亚型鉴定后的病原学监测结果、暴发疫情资料等数据应用χ2检验和时间序列移动平均法进行分析。结果 2010-2014年哨点医院共监测报告ILI病例651241万例,所在门急诊就诊病例16236264万例,ILI所占百分比平均为4.01%。4个监测年度报告的ILI%分别为3.79%、3.41%、4.59%、4.19%。相同年度月份间ILI%差异均有统计学意义,P值均<0.01。ILI主要分布在小年龄人群,尤其是0~4岁组,均占到50%以上。4个监测年度平均分离阳性率分别为1.20%、6.38%、7.35%和7.15%,每一年优势毒株不同,分别是H3N2型、B型、H3N2型和甲型H1N1型。暴发疫情多发生于冬春季,且多为托幼机构和学校。结论 辽宁省流感流行季节性仍明显,12月份次年3月份高发。流感病毒多混合流行,优势毒株交替出现且有一定的规律,2010年后季节性H1N1型流感基本消失。Abstract: Objective To examine epidemic situation and pathogenic characteristics of influenza in Liaoning province from 2010 to 2014 and to provide evidences for formulating preventive and control strategies.Methods Chi-square test and time series moving average method were used to analyze weekly data on influenza-like illness(ILI) from the 21 influenza sentinel hospitals and pathogen surveillance results of subtypes identified with hemagglutination inhibition test after viral isolation for specimens from ILI with Madin-Darby canine kidney(MDCK) cells from 2010 to 2014.Results During the 4-year period,the reported ILI cases accounted for 4.01% of all outpatient clinic visits(651241 out of 16 236264),with the yearly proportion of 3.79%,3.41%,4.59%,and 4.19%,respectively.The proportion of ILI in all outpatient clinic visits was significantly different among the months during a year(P<0.05).The ILI cases reported were mainly the people under the age of 15 years and 50% of the cases were small children aged 0-5 years.During the period,the yearly positive rate of influenza virus isolation were 1.20%,6.38%,7.35%,and 7.15%,with the dominant strain of H3N2,B,H3N2,and H1N1,respectively.The influenza outbreaks mainly occurred in winter and spring and at schools and childcare facilities.Conclusion The seasonal variation of influenza epidemic is obvious with a peak from December of a year to March of next year and the prevalent influenza strains are multiple with the alternations of dominant strains in Liaoning province from 2010 to 2014.
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Key words:
- influenza /
- epidemic character /
- variation tendency
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[1] Qi JL.The origin of pandemic strains of influenza virus status of the study[J].Foreign Medical Sciences(Section of Virology),1998,5(2):41-45.(in Chinese)祁俊林.流感病毒大流行株起源研究的现状[J].国外医学·病毒学分册,1998,5(2):41-45. [2] 中国疾病预防控制中心.全国流感监测方案(2010年版)[S].2010. [3] 中国疾病预防控制中心.全国流感监测技术指南[S].北京:中国疾病预防控制中心,2011. [4] 苏杨,马玲,王开利,等.黑龙江省2009-2012年流感监测及流行特征分析[J].中国公共卫生,2013,29(5):745. [5] 张静,杨维中,郭元吉,等.中国2001-2003年流行性感冒流行特征分析[J].中华流行病学杂志,2004,25(6):461-465. [6] Viboud C,Wladimir JA,Simonsen L,et al.Influenza in tropical regions[J].PLoS Med,2006,3(4):468-471. [7] Paget WJ,Meerhoff TJ,Meijer A.Epidemiological and virological assessment of influenza activity in Europe during the 2006-2007 season[J].Euro Surveill,2008,13(34):8958. [8] Jonathan S,Nguyen-Van T,Hampson AW.The epidemiology and clinical impact of pandemic influenza Vaccine,2003,21:1752-1768. [9] 高燕,方立群,张勇,等.中国大陆季节性流感活动的时空分布特征[J].中华流行病学杂志,2009,30(11):1097-1103. [10] 韩建平,刘昌顺,方欣.流行性感冒疫苗的效果观察[J].中国计划免疫,2000,6(1):25-27. [11] Nair H,Lau E,Brooks W,et al.An evaluation of the emerging vaccines against influenza in children[J].BMC Public Health,2013,13(Suppl3):S14. [12] 蓝雨,黄维娟,隋竑弢,等.甲流病毒的出现导致季节性H1N1流感病毒所受的纯化选择增强[J].病毒学报,2013,29(2):143-147. -

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