Effects of Physalis alkekengi water extraction on liver and blood lipid levels of rats with high fat diet
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摘要: 目的 探讨酸浆水提物对实验性高脂血症大鼠血脂水平的影响。方法 40只Wistar大鼠随机分为正常组,模型组和酸浆低、中、高剂量组。除正常组外均喂高脂饲料,酸浆低、中、高剂量组每天以1.5、7和37.5 g/kg酸浆水提物灌胃,连续30 d,测定大鼠血清总胆固醇(TC)、血清甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),计算肝脏指数。结果 酸浆低、中、高剂量组TG分别为(0.42±0.08)、(0.44±0.11)、(0.39±0.09)mmol/L,均低于模型组(0.56±0.16)mmol/L(P<0.05),而TC、LDL-C、HDL-C各组与模型组则无明显差异;酸浆各剂量组肝脏指数均低于模型组(P<0.05)。结论 酸浆水提物具有一定的降血脂作用。
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关键词:
- 酸浆 /
- 肝脏 /
- 总胆固醇(TC) /
- 高密脂蛋白胆固醇(HDL-C) /
- 血清甘油三酯(TG)
Abstract: Objective To study effects of Physalis alkekengi water extraction on blood lipid levels of experimental rats with hyperlipidemia.Methods Forty male Wistar rats were randomly divided into five groups:a normal group,a hyperlipidemia model group and low-,medium-,and high-dose Physalis alkekengi treatment groups.The rats in the four groups other than the normal group were fed with high fat feedstuff;the rats in the three treatment groups were gavaged with Physalis alkekengi water extraction at the doses of 1.5,7.5,and 37.5g/kg once a day continuously for 30 days.Then serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low density lipo-protein cholesterol(LDL-C) were detected and liver indexes were determined for all the rats.Results The TG contents of the rats in the three of Physalis alkekengi treatment groups were 0.42±0.08,0.44±0.11,and 0.39±0.09 mmol/L,respectively and were all lower than that in the model group(0.56±0.16 mmol/L)(all P<0.05),whereas the contents of TC,LDL-C,and HDL-C in the treatment groups were not significantly different compared to those in the model group(all P<0.05).The average liver indexes of the three Physalis alkekengi treatment groups were lower than that of the model group(all P<0.05).Conclusion Physalis alkekengi water extraction could reduce blood lipid at a certain extent in rats.-
Key words:
- Physalis alkekengi water extraction /
- liver /
- TC /
- HDL-C /
- TG
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