Abstract: Objective To investigate the prevalence and correlate factors of club drug use among middle school students in Yunfu city of Guangdong province,and to provide evidences for making strategies and measures to prevent drug use.Methods Totally 3055 students were recruited from middle schools by using two-stage stratified cluster randomly sampling,and were asked to answer a questionnaire anonymously.Results The rate of club drug use was 1.05%(32/3055)among the students(1.41 for the males and 0.63% for the females).The rate of club drug use were 0.64%(10/1564),1.22%(15/1226),and 2.26%(6/265)for the students of junior high school,high school,and vocational school,respectively.Among the five club drugs reported by the students,the use rate of ephedrine,ecstasy,Magu pill,and methamphetamine wrer 0.65%(20/3055),0.75%(23/3055),0.65%(20/3055),and 0.75%(23/3055),respectively,with the highest use rate of 0.98%(30/3055)for ketamine.Multivariate logistic regression analyses indicated that the determinants of the drug use were the relationship with classmates,smoking of the father,going to karaoke room,bars or ballroom frequently,and cigarette smoking.Conclusion The prevalence of club drug use is at a general level and poor relationship with classmates,smoking of father,going to karaoke room,bars,or ballroom frequently,and cigarette smoking are risk factors of club drug use among middle school students in Yunfu city.