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癌胚抗原相关细胞粘附因子19与乳腺癌相关基因关系

于洪涛 唐大海

于洪涛, 唐大海. 癌胚抗原相关细胞粘附因子19与乳腺癌相关基因关系[J]. 中国公共卫生, 2016, 32(1): 105-107. doi: 10.11847/zgggws2016-32-01-31
引用本文: 于洪涛, 唐大海. 癌胚抗原相关细胞粘附因子19与乳腺癌相关基因关系[J]. 中国公共卫生, 2016, 32(1): 105-107. doi: 10.11847/zgggws2016-32-01-31
YU Hong-tao, TANG Da-hai. Clinical significance and relationship of CEACAM19 mRNA expression with ER,PR and Her-2 in breast cancer patients[J]. Chinese Journal of Public Health, 2016, 32(1): 105-107. doi: 10.11847/zgggws2016-32-01-31
Citation: YU Hong-tao, TANG Da-hai. Clinical significance and relationship of CEACAM19 mRNA expression with ER,PR and Her-2 in breast cancer patients[J]. Chinese Journal of Public Health, 2016, 32(1): 105-107. doi: 10.11847/zgggws2016-32-01-31

癌胚抗原相关细胞粘附因子19与乳腺癌相关基因关系

doi: 10.11847/zgggws2016-32-01-31
详细信息
    作者简介:

    于洪涛(1979-),男,辽宁沈阳人,主管检验师,硕士,研究方向:临床医学检验。

    通讯作者:

    唐大海:E-mail:tdh863@163.com

  • 中图分类号: R

Clinical significance and relationship of CEACAM19 mRNA expression with ER,PR and Her-2 in breast cancer patients

  • 摘要: 目的 研究癌胚抗原相关粘附因子19(CEACAM19)mRNA表达水平与乳腺癌患者雌激素受体(estrogen receptor,ER)、孕激素受体(progestrone receptor,PR)、Her-2(human Epidermal growth factor receptor type 2)及CA15-3(carbohydrate atigen 15-3)表达的关系及临床意义。方法 应用实时荧光定量聚合酶链式反应(real-time RT-PCR)方法检测52例乳腺原发癌和配对淋巴转移癌以及130例乳腺原发癌的CEACAM19 mRNA的表达水平,比较52例乳腺原发癌和配对淋巴转移癌以及130例乳腺原发癌的CEACAM19 mRNA的表达水平,分析CEACAM19 mRNA表达水平与ER、PR及Her-2表达的关系。结果 52例乳腺癌淋巴结转移癌CEACAM19 mRNA表达水平(0.788±0.87)明显高于原发癌(0.431±0.381)(t=-3.289,P<0.05)。130例患者中,115例有雌激素受体检测结果,其中雌激素受体阳性组80例,CEACAM19 mRNA高表达者34例(34/80,42.5%);雌激素受体阴性组35例,CEACAM19 mRNA高表达24例(24/35,68.6%),2组CEACAM19 mRNA高表达占比差异有统计学意义(P<0.05)。CEACAM19 mRNA表达水平与孕激素受体、Her-2及CA15-3表达无相关性。结论 CEACAM19 mRNA的表达水平与乳腺癌患者雌激素受体表达水平有关。
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出版历程
  • 收稿日期:  2015-06-29
  • 刊出日期:  2016-01-10

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