Abstract: Objective To evaluate the effect of internet plus intervention on knowledge, attitude and practice(KAP)about lipids abnormality among young and middle-aged persons with dyslipidemia for providing evidences for effectively control of the disorder.Methods Using cluster random sampling, 200 dyslipidemia patients aged 18 to 45 years were selected among physical examinees from two administrative institutions in Hainan province and then randomly assigned into an intervention group and a control group during a period from June to November 2013.An 18-months additional education program a bout KAP of dyslipidemia via internet was administered along with routine intervention to the participants of intervention group.By the end of the program, the differences in dyslipidemia KAP between the intervention group and the control group receiving only routine intervention were analyzed.Results At the end of the intervention, significant increases in the scores for dyslipidemia KAP were observed among the participants of the intervention group(27.88±5.42 vs.16.60±8.17, 7.73±2.19 vs.5.95±0.79, and 12.47±2.51 vs.8.79±3.09)(P<0.05 for all); while among the participants of the control group, only a significant increase in the score of dysplipidemia knowledge was observed(22.69±6.74 vs.16.75±9.21, t=2.146; P=0.0408) and no significant differences in the scores of attitude and practice about dyslipidemia were observed.There were no significant differences in the scores of dyslipidemia KAP between the intervention group and the control group before the 18-month intervention, whereas after the intervention, the participants of internet plus intervention group had significantly higher scores for dyslipidemia KAP than those of the control group(P<0.05 for all).Conclusion Additional health education via internet along with routine intervention could effectively promote KAP about blood lipids abnormality among young and middle-aged community persons with dyslipidemia.