Abstract: Objective To analyze temporal-spatial ditribution of hemorrhagic fever with renal syndrome (HFRS) in Zhejiang province and to identify high-risk areas for the prevention and control HFRS epidemics in Zhejiang province.Methods Descriptive epidemiological methods were adopted to describe the epidemic characteristics of HFRS in Zhejiang province from 2005 to 2014.Results A total of 5 712 HFRS cases were reported during the period with an average annual reported incidence of 1.34/100 000.The HFRS epidemics showed an obvious seasonal variation.Two peaks of incidence rate was observed from May to July in a year and from November to January of next year.The global autocorrelation analysis demonstrated a significant spatial correlation for the county (district) -specific annual incidence except for the incidences in 2011 and the spatial autocorrelation declined over the years.Besides,two temporal-spatial clusterings,both in eastern Zhejiang during the periods from January 2005 to June 2009 and September 2011 to August 2013,were identified and the two spatial clusters showed an expansion trend.Conclusion There were temporal-spatial clusterings of hemorrhagic fever of renal syndrome epidemics in Zhejiang province from 2009 to 2014 and effective control measures should be implemented in the areas with high-risk to prevent the spread of the disease.