脑梗死患者血脂组分与同型半胱氨酸血症关系

王宁宁; 杨晓珊; 张宏召; 赵景波; 梁庆成

doi:10.11847/zgggws2016-32-10-30

脑梗死患者血脂组分与同型半胱氨酸血症关系

Correlation between blood lipids and hyperhomocysteinemia in patients with cerebral infarction

摘要

摘要: 目的探讨脑梗死患者血脂与同型半胱氨酸是否有关联。方法利用在哈尔滨医科大学附属第二医院收集的884例患者资料，根据同型半胱氨酸水平分为2组，分析血脂组分与同型半胱氨酸血症的关系。结果血脂组分中高密度脂蛋白（HDL）与同型半胱氨酸血症有关（χ²=17.193，P<0.000 1），相关性分析得出OR（95% CI）=0.420（0.277～0.638）；调整年龄、性别、文化程度、吸烟、饮酒和糖尿病后，HDL仍与同型半胱氨酸血症有关，其OR（95% CI）=0.352（0.223～0.554）。结论在脑梗死患者中血脂成分HDL是同型半胱氨酸血症的保护性因素，降低HDL水平会增加发生同型半胱氨酸血症的危险性。

Abstract: Objective To investigate the correlations between blood lipids and hyperhomocysteinemia in patients with cerebral infarction.Methods A total of 884 cerebral infarction patients were selected from the Second Affiliated Hospital of Harbin Medical University and divided into two groups according to their levels of homocysteine.The association of blood lipids with hyperhomocysteinemia was analyzed.Results High density lipoproteinl cholesterol (HDL) was associated with hyperhomocysteinemia (χ²=17.193,P<0.0001),with an odds ratio (OR) (95% confidence interval95% CI) of 0.420 (0.277-0.638);HDL was also associated with hyperhomocysteinemia with the OR (95% CI)) of 0.352(0.223-0.554) after adjusting for age,sex,education level,smoking,alcohol drinking,and diabetes.Conclusion HDL is a protective factor of hyperhomocysteinemia in patients with cerebral infarction,and the decrease of HDL can increase the incidence of hyperhomocysteinemia.

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