Abstract: Objective To study the relationship between age-related changes of cerebrovascular hemodynamic indexes (CVHIs) and cerebrovascular aging.Methods We recruited adult physical examinees (≥ 20 years old) at 4 health care management centers of 4 general hospitals in 4 cities between January and October 2014.Demographic and other relevant information of the participants were collected and non-invasive detection of CVHIs were conducted among the participants.Gender-and age-specific variations in CVHI integral score,mean velocity (Vmean),minimum velocity (Vmin),pulse wave velocity (WV),and peripheral vascular resistance (Rv)were analyzed and compared.Results Totally 29 931 participants aged 20-94 years were included in the study.The abnormality rate of integral score (75)and mean score of CVHI were 23.4% and 82.18±23.65 for the male participants and 21.2% and 84.33±22.05 for the female participants,with significant differences (both P<0.05).Significant decreasing trends of CVHI integral score,Vmean,and Vmin and increasing trends of WV and Rv were observed with the increment of age among the participants(P<0.05 for all).There were significant between age group differences in all the CVHIs.The ages of 45 and 65 years were the two turning points for substantial decrease of CVHI integral score and the CVHI integral score decreases drastically and persistently among the participants more than 65 years old.Conclusion Abnormal changes in CVHI associated closely with the increment of age;cerebrovascular function declines obviously among the middle-aged and the elderly and the decline are dramatic and persistent among the people more than 65 years old.