SARS患者危险因素的Meta分析

黄平; 俞守义; 钟静

SARS患者危险因素的Meta分析

Meta-analysis on risk factors of SARS patients

摘要

摘要:
目的分析SARS患者危险因素, 为预防控制SARS疫情和治疗SARS患者提供参考依据。
方法检索与SARS危险因素和死亡分析的相关文献; 根据文献中的原始数据, 对各文献危险因素计算比值比(OR)和95%CI; 对计量资料, 合并和计算标准差平方、标准误、方差齐性检验, 进行t检验。汇集综合各检索文献报告, 对危险因素进行Meta分析。
结果并发症、基础疾病、患者年龄≥50岁、男性、淋巴细胞亚群CD8₊、CD3₊、CD4₊计数下降是SARS感染死亡的危险因素。
结论 SARS感染会严重削弱机体免疫功能, 在年老且伴有慢性疾病人群中表现尤为突出, 多数合并严重感染可能与机体细胞免疫功能受损有关。

Abstract:
Objective To provide scientific reference basis for preventing and controlling SARS epidemic and to treat clinical patients better by means of analysis of risk factors of SARS.
Methods The ORs and 95% CIs of patients in each papers were counted after referring to the published papers on SARS risk factors or and death analysis.T test was used for the measurement data with the pooled standard deviation, the pooled standard error, and the homogeneity test.Meta-analysis on the risk factors of SARS patients was carried out in comprehensive data.
Results The complication, the basic disease age ≥50, the male and the quantitatively decreasing in sub-groups of lymphocyte(CD8₊, CD3₊, CD4₊)were also the risk factors of SARS death.
Conclusion SARS infection could obviously impair the human immune-function, which was shown especially in the older and the basic disease.Those special cohorts mostly with severely infection might associated with the function depress of human cytoimmune.

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