低钙高镁饮水与大鼠骨代谢关系

龚元东; 高峰; 王宏; 曲宝恩; 卢连华; 李蔚; 郭明才

低钙高镁饮水与大鼠骨代谢关系

Effect of low-calcium and high-magnesium drinking water on bone metablism in rats

摘要

摘要:
目的研究低钙高镁饮水对骨代谢的影响及与骨质疏松的发病关系, 为山东省黄河入海口居民饮食结构的调整提供科学依据。
方法用低钙、高镁饮水喂养出生1个月的Wistar雌性大白鼠3个月, 测定与骨代谢有关的血清生化指标, 测量其股骨重量、骨密度, 观察骨组织的病理变化。
结果低钙高镁饮水的交互作用使大鼠的骨形成标志物明显增多, 股骨发生明显病理变化。
结论钙、镁元素对骨代谢有重要作用, 钙元素缺乏不是导致骨质疏松的唯一原因, 过量镁元素可引起成长期大鼠的骨丢失。

Abstract:
Objective To investigate the effect of magnesium supplement and calcium depletion drinking water on bone mass loss in rats.
Methods Wister female rats received purified dirnking water with Mg supplement and Ca deficiency.At 3rd month, blood was collected for serum Ca, Mg, P, alkaline phosphatase(ALP), BALP and ostecocalsin examination.Then the rats were sacrificed and the femurs were obtained for bone mineral density(BMD)and histomorphometry.
Results In both high-Mg water group and low-Ca and high Mg water group, serum ALP, BALP and osteocalcin were significantly higher than those of the other two groups, while serum Ca, Mg, P, body weight, weight and BMD of left femora did not change significantly medullary area, decreased cortical area and the trabecular did not change significantly compared with the other two groups.Histomorphometry demonstrated increased medullary area, decreased cortical area and the trabecular bone volume in low-Ca and high-Mg water group.
Conclusion Magnesium influenced bone metablism and a low calcium was not the only reason to induce osteoporosis.High magnesium might cause bone loss of growing rats.

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